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Nutritional Supplementation In The United States

Nutritional Supplementation In The United States

WHERE ARE WE NOW AND WHERE ARE WE GOING?

Monday, 20 January 2014 Written by Larry J Alexander OD FAAO Posted in Presentations

COUNCIL FOR RESPONSIBLE NUTRITION

2013 REPORT ON CONSUMERS  http://www.crnusa.org/consumersurvey/

SUMMARY PPT 

Slide1

THIS IS A POWERPOINT CREATED BY LARRY ALEXANDER, OD FAAO FROM A RECENT POSTING BY THE COUNCIL FOR RESPONSIBLE NUTRITION. I FOUND IT FASCINATING AND BELIEVE IT TO BE AN EXCELLENT PATIENT AND DOCTOR EDUCATIONAL TOOL.

THE FULL REPORT IS LOCATED ON http://www.crnusa.org/consumersurvey/Slide4Slide5Slide6Slide7Slide8Slide9Slide10

DOCTOR AND PATIENT EDUCATION FOR SUPPLEMENTATION IS LACKING IN THE U.S. CONTROVERSY REIGNS.

FOR EXAMPLE IF A PATIENT IS TAKING ANY SORT OF STATIN INCLUDING OTC RED YEAST RICE….WHAT SUPPLEMENT SHOULD THEY BE TAKING TO PROTECT THEIR HEART?

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096178/ 
Deichmann R, Lavie C, Andrews S. Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction. Ochsner J. 2010 Spring; 10(1): 16–21.

 

Studies Showing a Benefit of Coenzyme Q10 Administration

  1. Cooke M., Iosia M., Buford T., et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008;5:8. [PMC free article] [PubMed]
  2. Mizuno K., Tanaka M., Nozaki S., et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008;24((4)):293–299. Erratum in: Nutrition. 2008;24(6):616. Epub 2008 Feb 13. [PubMed]
  3. Kon M., Tanabe K., Akimoto T., et al. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr. 2008;100((4)):903–909. Epub 2008 Feb 20. [PubMed]
  4. Ylikoski T., Piirainen J., Hanninen O., Pentinnen J. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Mol Aspects Med. 1997;18((suppl)):283–290. [PubMed]
  5. Amadio E., Palermo R., Peloni G., et al. Effect of CoQ10 administration on VO2max and diastolic function in athletes. In: Folkers K., Littarru G. P., Yamagami T., editors. Biomedical and Clinical Aspects of Coenzyme Q10. New York, NY: Elsevier Science; 1991. pp. 513–520.
  6. Morisco C., Trimarco B., Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig. 1993;71((8)):S134–S136. [PubMed]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096178/
Deichmann R, Lavie C, Andrews S. Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction. Ochsner J. 2010 Spring; 10(1): 16–21.

Studies Showing No Benefit of Coenzyme Q10 Administration

  1. Snider I. P., Bazzarre T. L., Murdoch S. D., Goldfarb A. Effects of coenzyme athletic performance system as an ergogenic aid on endurance performance to exhaustion. Int J Sport Nutr. 1992;2((3)):272–286. [PubMed]
  2. Laaksonen R., Fogelholm M., Himberg J. J., Laakso J., Salorinne Y. Ubiquinone supplementation and exercise capacity in trained young and older men. Eur J Appl Physiol. 1995;72((1–2)):95–100. [PubMed]
  3. Rosenfeldt F., Hilton D., Pepe S., Krum H. Systemic review of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors. 2003;18((1–4)):91–100. [PubMed]
  4. Marcoff L., Thompson P. D. The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol. 2007;49((23)):2231–2237. [PubMed]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096178/
Deichmann R, Lavie C, Andrews S. Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction. Ochsner J. 2010 Spring; 10(1): 16–21.

CONCLUSION ON COENZYME Q10 FROM

Deichmann R, Lavie C, Andrews S. Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction. Ochsner J. 2010 Spring; 10(1): 16–21.

  1. Given the low risk of toxicity and the potential benefit in treating statin-induced myopathy, a trial of 200 mg of coenzyme Q10 daily should be considered for “AT RISK” patients.
  2. The elderly appear to be more susceptible to coenzyme Q10 deficiency. Athletes, who require the most efficient use of oxygen consumption by mitochondria for athletic performance, are also susceptible to mitochondrial dysfunction due to coenzyme Q10 deficiency.
  3. A population that would appear to gain the most benefit from coenzyme Q10 supplementation would be that population with all the mentioned characteristics. An elderly population of athletes receiving HMA Co-A reductase inhibitors (STATINS) would appear to be ideally suited to experiencing the greatest benefit from coenzyme Q10 supplementation, given the high risk of mitochondrial dysfunction from coenzyme Q10 deficiencies in this group.

TWO OTHER ESSENTIAL ISSUES ARE THE FACT THAT IF THE BODY DOES NOT EFFECTIVELY ASSIMILATE ANY FOOD OR DRUG OR SUPPLEMENT…IT IS OF NO VALUE. ALSO IF THE PATIENT CANNOT AFFORD THE SUPPLEMENT (63% SELECT BASED ON PRICE)…THE SCIENCE IS OF NO VALUE.

Slide16Slide17

 

CONTROL OF BIOAVAILABILITY

http://www.totalhealthinstitute.com/digestive-disorders/
WHAT ABOUT THE INFLAMED GUT?

10% OF AMERICANS OVER 40 HAVE DIVERTICULITIS

  • 10% OF AMERICANS HAVE GERD
  • 20-25% OF AMERICANS HAVE IRRITABLE BOWEL SYNDROME
  • 90% OF AMERICANS HAVE LEAKY GUT SYNDROME
  • OVER 40% OF AMERICANS REPORT MORE THAN ONE DIGESTIVE SYMPTOM/MONTH
  • 90% OF AMERICANS REPORT CONSTIPATION

THESE PEOPLE WILL NOT ASSIMILATE SUPPLEMENTS EFFECTIVELY

CONCLUSION ON THE OVERALL ISSUE

THERE ARE MORE QUESTIONS THAN ANSWERS AND THE PUBLIC AND HEALTH CARE PROVIDERS ARE WOEFULLY UNDER-EDUCATED

 

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Larry J Alexander OD FAAO

Larry J Alexander OD FAAO

Dr. Alexander (1948-2016) was a 1971 graduate of Indiana University School of Optometry. He served in the US Navy then served as a Professor at the University of Alabama Birmingham School of Optometry. Larry contributed to a number of chapters in textbooks and has published three editions of Primary Care of the Posterior Segment, as well as contributed to the professional literature. He also lectured extensively in the area of ocular and systemic disease. His areas of special interest included dysfunctional tear syndrome, glaucoma and macular degeneration.  His lessons are the basis for this site and he will be dearly missed. 

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